Research Article
Hemin and Zinc Protoporphyrin IX Affect Granisetron Constipating Effects In Vitro and In Vivo
Table 3
Effect of in vitro administration of hemin alone or in combination with granisetron (G) on the components of EFS response of duodenal preparations.
| | Treatments (M) | Area under the curve (% SNP) | | Minimum value (% mean basal tone) | | Off contraction (% mean basal tone) | | | 3 Hz | 5 Hz | 10 Hz | 3 Hz | 5 Hz | 10 Hz | 3 Hz | 5 Hz | 10 Hz |
| | Basal | | | | | | | | | | | | | | Hemin 10 | | | | 0.05 | | | | 0.05 | | | | n.s. | | Hemin + G 0.1 | | | | n.s. | | | | 0.05 | | | | n.s. | | Hemin + G 0.3 | | | | n.s. | | | | n.s. | | | | n.s. | | Hemin + G 1 | | | | n.s. | | | | n.s. | | | | n.s. |
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