Research Article
Formulation Development and Evaluation of Fast Disintegrating Tablets of Salbutamol Sulphate for Respiratory Disorders
Table 5
Evaluation parameters for the optimization of sodium starch glycolate.
| | Sr. no. | Evaluation parameters | F1
(1%) | F2
(2%) | F3
(4%) | F4
(6%) | F5
(8%) | F6
(10%) |
| | 1 | Weight variation (IP) | Passed | Passed | Passed | Passed | Passed | Passed | | 2 | Friability (%) | 0.8 | 0.8 | 0.1 | 0.3 | 0.1 | 0.1 | | 3 |
*Hardness (Kg/cm2) ± S.D | 2.2 ± 0.57 | 1.6 ± 0.28 | 1.5 ± 0.28 | 1.5 ± 0.32 | 2.0 ± 0.57 | 1.8 ± 0.28 | | 4 |
**Disintegration time (sec) ± S.D | 80 ± 2.34 | 59 ± 6.67 | 34 ± 2.63 | 48 ± 6.38 | 78 ± 7.39 | 95 ± 6.97 |
|
|
Average of three determinations.
**Average of six determinations.
|
