Formulation Development and Evaluation of Fast Disintegrating Tablets of Salbutamol Sulphate for Respiratory Disorders
Table 6
Evaluation parameters for the optimization of polyvinylpyrrolidone (PVP K-30) or microcrystalline cellulose as binder with optimized concentration of sodium starch glycolate.
Evaluation parameters
Weight variation (IP)
Friability (%)
*Hardness (Kg/cm2) ± S.D
**Disintegration time (sec) ± S.D
Formula no.
F1
Passed
0.1
2.2 ± 0.28
60 ± 1.78
F2
Passed
0.2
1.8 ± 0.28
45 ± 1.67
F3
Passed
0.5
2.0 ± 0.00
69 ± 2.89
F4
Passed
0.3
3.2 ± 0.76
83 ± 2.40
F5
Passed
0.3
1.6 ± 0.50
90 ± 5.16
F6
Passed
0.8
2.5 ± 0.50
120 ± 5.77
F7
Passed
0.8
2.0 ± 0.00
145 ± 5.43
F8
Passed
0.1
1.5 ± 0.50
36 ± 2.13
F9
Passed
0.1
1.5 ± 0.28
47 ± 1.34
F10
Passed
0.2
1.5 ± 0.28
62 ± 1.10
F11
Passed
0.1
1.8 ± 0.28
75 ± 1.32
F12
Passed
0.1
1.5 ± 0.28
82 ± 2.08
F13
Passed
0.1
1.8 ± 0.28
96 ± 0.84
F14
Passed
0.1
1.8 ± 0.28
105 ± 0.73
Average of three determinations.
**Average of six determinations.
