Research Article
Formulation Development and Evaluation of Fast Disintegrating Tablets of Salbutamol Sulphate for Respiratory Disorders
Table 8
Stability data of salbutamol sulphate FDT at room temperature and at ambient humidity.
| | Time interval | Data of three primary batches on | | 0 day | 15th day | 30th day | | Evaluation parameters | B-1 | B-2 | B-3 | B-1 | B-2 | B-3 | B-1 | B-2 | B-3 |
| |
*Hardness (Kg/cm2) ± S.D | 1.5 ± 0.29 | 1.8 ± 0.29 | 1.5 ± 0.29 | 1.5 ± 0.00 | 1.5 ± 0.00 | 1.7 ± 0.29 | 1.5 ± 0.00 | 1.5 ± 0.29 | 1.5 ± 0.29 | | Friability (%) | 1 | 0.6 | 1 | 0.2 | 0.3 | 0.2 | 0.1 | 0.1 | 0.1 | |
*Drug content uniformity (mg) ± S.D | 100.8 ± 3.36 | 95.6 ± 2.34 | 93.8 ± 1.24 | 99.5 ± 2.14 | 94.5 ± 2.67 | 94.8 ± 1.23 | 98.3 ± 2.74 | 95.4 ± 2.36 | 95.7 ± 1.71 |
**Disintegration
time (sec) ± S.D | 39 ± 2.28 | 47 ± 1.80 | 42 ± 3.01 | 42 ± 3.97 | 50 ± 4.52 | 47 ± 1.66 | 46 ± 2.83 | 49 ± 2.52 | 48 ± 3.75 |
|
|
Average of three determinations/batch.
**Average of six determinations/batch.
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