Research Article
Formulation Development and Evaluation of Fast Disintegrating Tablets of Salbutamol Sulphate for Respiratory Disorders
Table 9
Stability data of salbutamol sulphate FDT at temperature (40° ± 2°C) and at ambient humidity.
| | Time interval | Data of three primary batches on | | 0 day | 15th day | 30th day | | Evaluation parameters | B-1 | B-2 | B-3 | B-1 | B-2 | B-3 | B-1 | B-2 | B-3 |
| |
*Hardness (Kg/cm2) ± S.D | 1.5 ± 0.29 | 1.8 ± 0.29 | 1.5 ± 0.29 | 2.5 ± 0.00 | 2.2 ± 0.29 | 2.5 ± 0.00 | 2.5 ± 0.00 | 2.5 ± 0.29 | 3.2 ± 0.29 | | Friability (%) | 1 | 0.6 | 1 | 0.1 | 0.2 | 0.9 | 0.6 | 0.5 | 0.1 | |
*Drug content uniformity (mg) ± S.D | 100.8 ± 3.36 | 95.6 ± 2.34 | 93.8 ± 1.24 | 98.5 ± 2.14 | 99.4 ± 2.67 | 91.42 ± 3.64 | 92.8 ± 1.98 | 99 ± 1.65 | 97.6 ± 3.63 | |
**Disintegration time (sec) ± S.D | 39 ± 2.28 | 47 ± 1.80 | 42 ± 3.01 | 49 ± 2.38 | 55 ± 3.08 | 51 ± 1.76 | 55 ± 2.09 | 61 ± 1.89 | 58 ± 2.96 |
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Average of three determinations/batch.
**Average of six determinations/batch.
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