Alterations of Hormone-Sensitive Adenylyl Cyclase System in the Tissues of Rats with Long-Term Streptozotocin Diabetes and the Influence of Intranasal Insulin
Figure 3
The inhibitory effects of hormones on forskolin-stimulated AC activity in the tissues of diabetic and control rats with and without I-I treatment. C: control animals; CI: control animals treated with intranasal insulin (I-I); D: diabetic animals with 210-day streptozotocin-induced diabetes mellitus of the type 1 (T1DM); DI: diabetic animals treated with I-I; 1, 3, and 7: somatostatin (10−6 M) in the heart, brain, and testes, respectively; 2 and 4: noradrenaline (10−5 M) in the heart and brain, respectively; 5: bromocriptine (10−5 M) in the brain; 6: 5-nonyloxytryptamine (10−5 M) in the brain. The stimulating effect of forskolin (10−5 M) on the basal AC activity is taken as 100%. Values are the weighted mean ± weighted standard deviation of three individual experiments, each performed in triplicate. * and *** denote the statistically significant difference between Groups C and D at and 0.001; #, ##, and ###, the same between Groups D and DI at , 0.01, and 0.001; &, &&, and &&&, the same between Groups CI and DI at , 0.01, and 0.001, respectively.
