Rejection of D^d skin grafts in mice infused with resting B cells. (a) Naive mice received no injection, 10⁷ purified MHC-D^d B cells, or 10⁷ purified CD2-D^d B cells intravenously: (filled triangle) = MHC-D^d; (open circle) = CD2-D^d; and the dashed line = none. Mice were grafted with MHC-D^d tail skin 2 weeks later. MST of skin grafts: naive mice = 12 days (); naive plus CD2-D^d B cell = 18 days ( versus naive, by log-rank) (); naive plus MHC-D^d B cell = 9 days ( versus naive) (). (b) D^d-primed mice received no injection, 10⁷ purified MHC-D^d B cells, or 10⁷ purified CD2-D^d B cells intravenously: filled triangle = MHC-D^d; open circle = CD2-D^d; and the dashed line = none. Mice were grafted with MHC-D^d tail skin 2 wks later. MST of skin grafts: primed mice = 8.5 d (); priming plus CD2-D^d B cell = 12 d ( versus primed; versus naive) (); priming plus MHC-D^d B cell = 11.5 days ( versus primed; versus naive) ().