International Scholarly Research Notices

Research Article

Statistical Optimization and In Vitro Evaluation of Metformin Hydrochloride Asymmetric Membrane Capsules Prepared by a Novel Semiautomatic Manufacturing Approach

Table 2

Levels of independent variables taken for optimization of metformin hydrochloride formulations.
Independent variablesLevels used
LowHigh
—propylene glycol (plasticizer) (% )1520
—potassium chloride (osmogent) (mg)75125
—fructose (osmogent) (mg)75125
Metformin.HCl (mg)500
Purified talc (mg)3
Magnesium stearate (mg)2