International Scholarly Research Notices

Research Article

Statistical Optimization and In Vitro Evaluation of Metformin Hydrochloride Asymmetric Membrane Capsules Prepared by a Novel Semiautomatic Manufacturing Approach

Table 3

Experimental design summary of the metformin hydrochloride formulations.
S. NoFormulation codeIndependent variablesDependent variable
 
Conc. of PG (% )		  
Conc. of KCl (mg)		  
Conc. of Fructose (mg)		Time taken for 100% drug release
( )
1F1M1−1+1−18
2F1M2−1−1+116
3F1M3−1+1+18
4F1M4−1−1−110
5F2M1+1+1−111
6F2M2+1−1+118
7F2M3+1+1+16
8F2M4+1−1 −113
(Actual values: , +1 = 20% , −1 = 15% ; , +1 = 125 mg, −1 = 75 mg; C, +1 = 125 mg, −1 = 75 mg).