International Scholarly Research Notices

Research Article

Statistical Optimization and In Vitro Evaluation of Metformin Hydrochloride Asymmetric Membrane Capsules Prepared by a Novel Semiautomatic Manufacturing Approach

Table 4

Comparative drug release kinetics for the design formulations.


Form. code	Kinetic Models										Korsmeyer peppas parameter	Best fit model
	Zero-order plot		First-order plot		Higuchi plot		Korsmeyer-peppas		Hixson-crowell


F1M1	0.995	7.414	0.899	−0.145	0.900	20.784	0.994	4.365	0.949	−0.037	1.252	Zero-order
F1M2	0.992	8.786	0.775	−0.243	0.892	23.547	0.995	4.579	0.903	−0.051	1.315	Peppas
F1M3	0.973	13.856	0.956	−0.363	0.948	32.762	0.987	14.543	0.987	−0.082	0.988	Peppas
F1M4	0.993	4.589	0.967	−0.061	0.896	12.860	0.996	3.909	0.978	−0.018	1.062	Peppas
F2M1	0.988	10.341	0.896	−0.247	0.938	27.000	0.988	10.069	0.967	−0.057	1.021	Peppas
F2M2	0.993	11.054	0.840	−0.234	0.912	25.665	0.997	9.740	0.919	−0.057	1.066	Peppas
F2M3	0.992	16.749	0.856	−0.445	0.945	34.387	0.991	17.602	0.945	−0.097	0.970	Zero-order
F2M4	0.971	5.188	0.931	−0.073	0.910	14.752	0.963	9.775	0.950	−0.021	0.681	Zero-order
Mktd	0.8848	9.822	0.843	−0.319	0.997	28.862	0.992	25.832	0.968	−0.062	0.556	Matrix