Research Article
Molecular Biology of Breast Cancer in the Horn of Africa: Case Series—A Pilot Study of Breast Cancer from Eritrea
Table 1
Summary of the clinical pathological characteristics of molecular subtypes of breast cancer in Eritrea.
| | | | Molecular subtypes of breast cancer | |
| | Characteristics | All cases
(100) | Luminal A
(59) | Luminal B
(4.5) | HER2 type
(4.5) | Basal-like
(9.1) | Unclassified
(22.7) | value | | (%) | (%) | (%) | (%) | (%) | (%) |
| | Sex | | | | | | | | | Male | 2 (9.1) | 2 (18.2) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0.70 | | Female | 20 (90.9) | 11 (84.6) | 1 (100) | 1 (100) | 2 (100) | 5 (100) | | | Age in years | | | | | | | | | <50 | 13 (63.6) | 7 (63.6) | 1 | 0 | 2 | 4 (80) | 0.26 | | >50 (age unknown in one patient) | 8 (36.4) | 4 (36.4) | 0 | 2 | 0 | 2 (20) | | | Mean (SD) | 47.7 (12.9) | | | | | | | | Histologic type | | | | | | | | | IC (NST) | 20 (91) | 10 (90.1) | 1 | 2 | 1 | 6 | 0.18 | | Colloid | 1 (4.5) | 1 (9.9) | 0 | 0 | 0 | 0 | | | Metaplastic breast carcinoma (SCC) | 1 (4.5) | 0 | 0 | 0 | 1 | 0 | | | Nottingham grade | | | | | | | | | I | 2 (9.1) | 2 (18.2) | 0 | 0 | 0 | 0 | 0.031 | | II | 7 (31.8) | 6 (54.5) | 0 | 0 | 0 | 1 (16.7) | | | III | 13 (59.1) | 3 (27.3) | 1 | 2 | 2 | 5 (83.3) | | | LN* metastasis | | | | | | | | | Positive | 11 (50) | 6 (54.5) | 1 | 1 | 1 (50) | 2 (33.3) | 0.44 | | Negative | 8 (36.4) | 5 (45.5) | 0 | 0 | 0 | 2 (33.3) | | | NA | 3 (13.6) | 0 | 0 | 0 | 1 (50) | 2 (33.3) | | | Tumor size | | | | | | | | | ≤2 cm | 1 (4.5) |
1 (9.1) | 0 | 0 | 0 | 0 | 0.84 | | 2.1–5 cm | 12 (54.6) | 6 (54.5) | 1 | 1 | 0 | 4 | | | >5 cm | 7 (31.8) | 4 (36.4) | 0 | 1 | 1 | 1 | | | NA | 2 (9.1) | 0 | 0 | 0 | 1 | 1 | | | LVI** | | | | | | | | | Positive | 3 (13.6) | 1 (9.9) | 1 | 0 | 1 (50) | 0 | 0.04 | | Negative | 19 (86.4) |
10 (90.1) | 0 | 2 | 1 (50) | 6 | | | ITN+ | | | | | | | | | Positive | 10 (45.4) | 4 (36.4) | 1 | 2 | 0 | 3 (50) | 0.11 | | Negative | 12 (54.6) | 7 (63.6) | 0 | 0 | 2 | 3 (50) | |
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ITN+: invasive tumour necrosis, LVI**: lymphatic vessel invasion, LN*: lymph node, IC (NST): invasive carcinoma of no special type, NA: Nonavailable, : probability, SD: standard deviation, SCC: squamous cell carcinoma.
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