International Scholarly Research Notices

Review Article

VGLUTs in Peripheral Neurons and the Spinal Cord: Time for a Review

Table 5

Changes in the expression of VGLUTs in DRGs, spinal cord, and/or LSCs, upon peripheral nerve injury (axotomy of the sciatic nerve) or hindpaw inflammation.


Tissue	Species	Lesion type	Protein			mRNA
Tissue	Species	Lesion type	VGLUT₁	VGLUT₂	VGLUT₃	VGLUT₁	VGLUT₂	VGLUT₃

DRG	Mouse	Axotomy	▼ ▼ [54]	▼ [54]	NE	No change [136]	No change [136]	▼ [136]
	Mouse	Hind. inflam.	NE	NE	NE	No change [136]	No change [136]	No change [136]
	Rat	Axotomy	NE	NE	NE	NE	NE	NE
	Rat	Hind. inflam.	NE	NE	NE	NE	NE	NE

Spinal cord	Mouse	Axotomy	▼ ▼▼ (LII-VIII, IX) [54]	No change [54]	NE	No change [136]	No change [136]	No change [136]
	Mouse	Hind. inflam.	NE	NE	NE	No change [136]	No change [136]	No change [136]
	Rat	Axotomy	▼ ▼▼ (LII-VIII-IX) [214]	NE	NE	NE	NE	NE
	Rat	Hind. inflam.	NE	NE	NE	NE	NE	NE

LSC	Mouse	Axotomy	No change [60]	▲ [60]	NE	No change [60]	▲ [60]	No change*
	Mouse	Hind. inflam.	NE	NE	NE	NE	NE	NE
	Rat	Axotomy	NE	NE	NE	NE	NE	NE
	Rat	Hind. inflam.	NE	NE	NE	NE	NE	NE

Arrowhead up: upregulation; arrowhead down: downregulation; NE: not evaluated; : plus an increase in VGLUT₂-LI in small neuron profiles; *unpublished data; tissue has been processed and NPs quantified according to references [54, 60–62].