Stability Study of Darunavir Ethanolate Tablets Applying a New Stability-Indicating HPLC Method

<table class="table-group" id="tab3"><tr><td><table class="table"><tr><td class="thead-hr" colspan="3"><hr/></td></tr><tr class="thead"><td align="left">Method</td><td align="center">Added amount (<i>μ</i>g/mL)</td><td align="center">Recovery<sup>a</sup> (%) ± RSD</td></tr><tr><td class="thead-hr" colspan="3"><hr/></td></tr><tr><td align="left" rowspan="6">Chromatographic method</td><td align="center">6.0</td><td align="center">101.5 ± 0.5</td></tr><tr><td align="center">9.0</td><td align="center">99.9 ± 1.0</td></tr><tr><td align="center">12.0</td><td align="center">98.5 ± 0.6</td></tr><tr><td align="center">15.0</td><td align="center">98.8 ± 1.2</td></tr><tr><td align="center">18.0</td><td align="center">98.9 ± 0.7</td></tr><tr><td align="center">21.0</td><td align="center">98.9 ± 1.0</td></tr><tr class="table-tr"><td colspan="3"><hr class="tbody-hr"/></td></tr></table></td></tr><tr class="table-fn"><td><sup>
									a</sup>Mean of three replicates.<br/></td></tr></table>

Recovery data of standard solutions added to the placebo analyzed by the proposed chromatographic method.

Chromatography Research International

tab3

Table 3

Table 3: Stability Study of Darunavir Ethanolate Tablets Applying a New Stability-Indicating HPLC Method 