Research Article

Ischemia Induces Release of Endogenous Amino Acids from the Cerebral Cortex and Cerebellum of Developing and Adult Mice

Figure 2

Time course of basal (- -) and K+-evoked (- -) glutamate release from cerebral cortical slices in normoxia and basal (-∆-) and K+-stimulated (-▴-) glutamate release in ischemia in 7-day-old (a) and 3-month-old (b) mice. The results are means of 4–8 independent experiments with SEMs indicated. Ischemia significantly ( ) enhanced the release in both age groups, but K+ stimulation was effective only in normoxia in both. Note the fivefold difference in the scale of the -axis in panels (a) and (b).
839036.fig.002a
(a)
839036.fig.002b
(b)