Research Article

Ischemia Induces Release of Endogenous Amino Acids from the Cerebral Cortex and Cerebellum of Developing and Adult Mice

Figure 4

Average release of aspartate, glycine and glutamine (a) and alanine, serine and threonine (c) from cerebral cortical slices from 7-day-old mice and from cerebral cortical slices from 3-month-old mice ((b) and (d)) during the superfusion period of 32 to 50 min. The first open bars show the basal, and the second right-hatched bars the K+-stimulated release in normoxia, the third left-hatched bars the basal, and the fourth cross-hatched bars the K+-stimulated release in ischemia. The results are mean values SEM of 4–8 independent experiments. Note the twofold differences in the scale of the -axes in panels (a), (b), (c), and (d). The statistically significant difference from the corresponding unstimulated release in normoxia: .
839036.fig.004a
(a)
839036.fig.004b
(b)
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(c)
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(d)