(i) Proinflammatory cytokine plays a key role in the etiology of periodontal disease
(i) Involved in the pathogenesis of periodontal diseases
(ii) Stimulates induction of molecules to amplify tissue response
(ii) “A difference of concentration of PGE2 in GCF was shown in patients with gingivitis and periodontitis” by Offenbacher et al. in the year 1986 [47].
(iii) The level of cytokines proportionately correlates with periodontal parameters adjusting for the confounders
(iv) Increasing IL levels increase the risk of periodontal disease by 45-fold [46]
