Research Article

Evaluation of Packed-Bed Reactor and Continuous Stirred Tank Reactor for the Production of Colchicine Derivatives

Table 4

Performance comparison of STR and PBR of lab scale for the production of 3-DMC at an equal DO level.

ParametersCSTRPBR

(g/L)1.225
(g/L)18025
(mM)3535
Productivity (g/L/h)4.78 [13]6.58
Bioconversion time (h)7232

(CSTR) continuous stirred tank reactor; (PBR) packed-bed reactor; : initial cell concentration; : maximum cell concentration; : initial substrate (colchicine) concentration g/L.