International Scholarly Research Notices

Review Article

The Human Frontal Lobes and Frontal Network Systems: An Evolutionary, Clinical, and Treatment Perspective

Table 7

Neuropathologic subtypes.


Histopathology	Subtypes	Clinical	Chromosome

Tauoapthy	PiD	bvFTD, PNFA	17 (MAPT)
	PSP	PSP
	CBD	CBD, PNFA
	AGD	bvFTD, MND
	MST

TDP-43	Type 1	bvFTD
	Type 2	SD, MND	9 (IFT74)
	Type 3	bvFTD, SD, PNFA	17 (PGRN)
	Type 4	bvFTD, myopathy, Paget’s	9 (VCP)

FTLD-UPS	FTD 3	bvFTD	3 (CHMP2B)

BIBD	—	FTD-MND

FTLD-IF	—	—	—

FTLD-ni	—	—	—

PiD: Pick’s disease, PSP: progressive supranuclear palsy, CBD: cortico-basal-ganglionic degeneration, AGD: argyrophilic grain disease, MND: motor neuron disease, PNFA: progressive nonfluent aphasia, SD: semantic disease/variant, MST: sporadic multisystem tauopathy, BIBD: basophilic inclusion body disease, FTLD IF: FTLD with intermediate filament inclusions, FTLD ni: FTLD with no inclusions, FUS: fused in sarcoma, NIF: neuronal intermediate filaments, VCP: valosin containing protein, CMBP 2B: charged multivesicular body protein 2B, MAPT: microtubule associated protein tau, TDP-43: TAR DNA binding protein 43, IFT74: intraflagellar transport protein 74.
Modified from Josephs [25].