Thymic Stromal Lymphopoietin Enhances Th2/Th22 and Reduces IL-17A in Protease-Allergen-Induced Airways Inflammation
Figure 2
Decreased pulmonary Th2 cytokine and chemokine responses in TSLPR−/− mice in response to HDM. Mice were immunized and challenged with HDM as before. IL-1, IL-13, IL-33, TSLP, CCL11 (Eotaxin-1), CCL17 (TARC), CCL22 (MDC), and CCL24 (Eotaxin-2) were measured in the lung homogenate by ELISA (a–h) from HDM treated WT and TSLPR−/− mice at 24 h after the third challenge. These experiments were performed twice ( mice per group). One representative experiment is shown. Values are the mean SEM of 8 mice per group. **; ***.
