Epilepsy Research and Treatment
Volume 2013 (2013), Article ID 983049, 6 pages
Review Article

The Role of Epilepsy Surgery in the Treatment of Childhood Epileptic Encephalopathy

1Department of Neurosciences, King Faisal Specialist Hospital and Research Center, Jeddah 21499, Saudi Arabia
2Department of Neurology, Children’s Mercy Hospital and Clinics, Kansas City, MO 64108, USA
3Division of Neurosurgery, College of Medicine, King Abdulaziz University, Jeddah 21589, Saudi Arabia
4Division of Neurological Surgery, King Abdulaziz University Hospital, P.O. Box 80215, Jeddah 21589, Saudi Arabia

Received 19 February 2013; Revised 25 March 2013; Accepted 29 March 2013

Academic Editor: Giangennaro Coppola

Copyright © 2013 Husam R. Kayyali et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Children with epileptic encephalopathy often have global impairment of brain function and frequent intractable seizures, which contribute further to their developmental disability. Many of these children have identifiable brain lesion on neurological imaging. In such cases, epilepsy surgery may be considered as a treatment option despite the lack of localized epileptic pattern on electroencephalogram (EEG). In this paper, we summarize the clinical features of epileptic encephalopathy syndromes and review the reported literature on the surgical approach to some of these disorders.