Longitudinal Imaging of Cancer Cell Metastases in Two Preclinical Models: A Correlation of Noninvasive Imaging to Histopathology
Figure 5
Correlation of [18F]FDG-PET imaging of melanoma cancer cell metastasis with histopathology. [18F]FDG accumulation in the lungs correlated with the extent and presence of metastasis by histopathology. (a) Representative fused image of PET/CT from 2 animals showing different levels of [18F]FDG accumulation. Correlation with tumor nodules in the lung is evident from paraffin section images of the lung stained with H&E. (b) Regression plot showing correlation between lung metastatic lesions identified by [18F]FDG-PET imaging and the percent of lung involvement of melanoma cancer cells calculated by histopathology. (c) Regression plot between BLI signal intensity of the thoracic region and the lung metastasis area (mm2) as calculated by histopathology. Correlation was calculated using Pearson correlation coefficient analysis.
