Advances in Biology

Review Article

The Role of the Actin Cytoskeleton and Lipid Rafts in the Localization and Function of the ABCC1 Transporter

Table 1

Dependence of ABC transporter localization (“Raft”) or function (“Efflux”) on lipids or cortical actin.


	ABCB1		ABCC1		Abcc1
	Raft	Efflux	Raft	Efflux	Raft	Efflux

Glycolipid depletion	n.d.	= [14]	= [14]	= [14]	n.d.	n.d.

Sphingolipid depletion	n.d.	= [18]	= [17, 18]	= [17, 18]	= [17]	= [17]

Cholesterol depletion (CO)	n.d.	n.d.	= [21]	= [21]	= [21]	= [21]

Cholesterol depletion (CD)	n.d.	n.d.	= [21]	↓ [21]	↓ [21]	↓ [21]

Cholesterol depletion (Lo/Ro)	n.d.	n.d.	n.d.	n.d.	↓ [21]	= [21]

Cortical actin depletion	= [30, 31]	= [30]	↓ [24]	↓ [24]	↓ [24, 31]	↓ [24]

The table summarizes the effects of depletion of lipid (sub)families or cortical actin on ABC transporter localization in lipid rafts and its efflux function. This is indicated for the ABC transporters ABCC1 (human), Abcc1 (murine), and ABCB1. Numbers indicate literature references. CO: cholesterol oxidase; CD: methyl--cyclodextrin; LO/RO: lovastatin/RO48-8071; =: no effect; ↓: reduced lipid raft association or efflux function; n.d.: not determined.