Research Article

Prediction of Spontaneous Regression of Cervical Intraepithelial Neoplasia Lesions Grades 2 and 3 by Proteomic Analysis

Table 1

List of 165 proteins identified with high significance filter in Proteome Discoverer.

Accession numberNumber of AAsMW [Da]DescriptionΣCoverage

2577760095310576926S proteasome non-ATPase regulatory subunit 11,1
9209099075786306Activating signal cointegrator 1 complex subunit 21,7
11963184343848626Activin A receptor, type I7,3
908192331651187556Afadin isoform 21,5
11287720123497Alpha-1-acid glycoprotein 115,9
11959859336639172Alpha-2-HS-glycoprotein5,7
224809474951106839Ankycorbin isoform B3,5
1195730079210573Apolipoprotein A-II52,2
1196212073000338317Apolipoprotein B (including Ag(x) antigen)0,8
7362208566572088ATPase WRNIP1; AltName: Werner helicase-interacting protein 12,4
857004021704191239ATP-binding cassette subfamily A member 32,1
1491695663369181ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial3,2
26076396365273680B-cell scaffold protein with ankyrin repeats isoform 32,8
410564272891Beta-trace {N-terminal}74,1
11963031961669142BTB and CNC homology 1, basic leucine zipper transcription factor 13,4
11061825065169567Cadherin-related family member 5 isoform 32
9320455175485485Calpain-7-like protein2,3
1196210192225242829Carbamoyl phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase0,6
21527426562670812Carnitine O-acetyltransferase2,1
11958855036139391CD44 antigen (Indian blood group)3,3
15110130155060746Centrosomal protein POC5 isoform 26,7
1711844513117350716Centrosome-associated protein 3500,9
283135365212382Chain A, human insulin100
28952659312013375Chain B, crystal structure of monomeric human cystatin C9,2
29627849512013562Chain B, crystal structure of the second bromodomain of human polybromo (protein polybromo-1)14,2
29578930815315779Chain B, human sod1 D124v variant64,7
29365190124328061Chain B, solution structure of double super helix model (apolipoprotein A-I)33,3
28952684422024615Chain B, structural basis of membrane-targeting by dock180 (dedicator of cytokinesis protein 1)8,6
29146353312713753Chain B, wild type human transthyretin (Ttr)38,6
289526762303428Chain D, enhancing the therapeutic properties of a protein by a desig binding site100
2949797221410Chain E, deoxy human normal adult hemoglobin56,7
2949797231460Chain G, deoxy human normal adult hemoglobin89
29532191837441579Chain J, model of alpha-actinin Ch1 bound to F-actin9,1
11963080274078794Chromosome 20 open reading frame 752,7
11956851215317486Chromosome 6 open reading frame 7510,5
1051850344449288Coagulation factor VII isoform B precursor3,4
1195813661261135504Cordon-bleu homolog (mouse)2,3
83582815899881Cornifin-B19,1
11960249631135475Cysteine/histidine-rich 14,2
1071996352059956Cytochrome P450 4F83,1
11958179671278265Cytoplasmic polyadenylation element binding protein 42,4
1196103012073237519Dedicator of cytokinesis 110,9
2014130211011277Dermcidin25,5
5574993247053503Desmin10,9
6305485250858371DNA nucleotidylexotransferase isoform 25,3
119614620977109666Endoplasmic reticulum to nucleus signalling 11,6
24418674974110429Exocyst complex component 41,5
173696861087123828Exportin-71,5
2274936343449418F-box only protein 15 isoform 13,5
1195704611769200655Fer-1-like 3, myoferlin (C. elegans)0,9
1195680191322142839Fibronectin type III domain containing 11,5
1312901818820994Gamma-glutamylcyclotransferase10,1
11959633814716448Ganglioside-induced differentiation-associated protein 1-like 110,2
4640930444348955Glutamate-rich protein 13,8
11962512921524427Glycoprotein M6A7,4
119621332947107158GREB1 protein1,5
15203161766972408GTP-binding protein 12,1
11962529845551153Guanylate cyclase 1, soluble, alpha 32,9
119583777947106793hCG16418242
119584015697604hCG181312217,4
1195973944919535890hCG192530,4
1195827788710173hCG198112612,6
1196108621925215078hCG19860531,6
11956845349154322hCG20302975,1
11957249057662385hCG20405844,3
119598528576808hCG204539729,8
450451720522768Heat shock protein beta-121
11958921114716045Hemoglobin, delta62,6
11958912546251643Hemopexin7,6
12192522122336Histone H1.35,9
590192237844440Hsp90 cochaperone Cdc373,7
1646849019411002Immunoglobulin heavy chain variable region18,1
173664672758313745Inositol 1,4,5-trisphosphate receptor type 10,6
1196230871257133685Insulin receptor substrate 41
2266941841179130077Integrin alpha-E1,7
26187861862369452Inter-alpha-trypsin inhibitor heavy chain H1 isoform C2,3
2747707450255848Interleukin-17 receptor B precursor2,6
4639780744949715Keratin, type I cuticular Ha73,3
19597286658458766Keratin, type I cytoskeletal 1022,6
23993888662362027Keratin, type I cytoskeletal 928,3
23805440664465999Keratin, type II cytoskeletal 130,1
23993865063965393Keratin, type II cytoskeletal 2 epidermal7,5
14381141159062340Keratin, type II cytoskeletal 511,9
503183956460008Keratin, type II cytoskeletal 6A14,2
23805440456460030Keratin, type II cytoskeletal 6B9
5980308956459988Keratin, type II cytoskeletal 6C16,3
9011002748353671Keratin, type II cytoskeletal 87,9
119619543916102928KIAA1024 protein2,1
1196007581047116840KIAA11284,3
1195838931420158295Kinesin family member 13B2,9
23156945862970939Lactoperoxidase isoform 3 preproprotein2,5
2743694863470618Lamin-A/C isoform 38,2
11959909022225734Latexin5,4
11962827639443749Mannosidase, alpha, class 1C, member 16,4
29045762439741734Mesoderm posterior protein 24,8
11550245149653464Mothers against decapentaplegic homolog 64
11957392427128644Myeloid cell leukemia sequence 1 (BCL2-related)7,4
1196104151737199228Myosin, heavy polypeptide 8, skeletal muscle, perinatal1,2
336670401048119352NACHT, LRR, and PYD domains-containing protein 82,7
3362486142948129Nesprin-2 isoform 24
9320487162870024Netrin-4 precursor2,4
1603323355890628699Neuroblast differentiation-associated protein AHNAK4,5
11962519452760213NIMA- (never in mitosis gene A-) related kinase 12,9
15663252571480686Nuclear protein MDM12,4
11957042680092490Nucleolar complex associated 3 homolog (S. cerevisiae)1,6
7474941251057244Olfactomedin-42,8
2443018363873293Outer dense fiber protein 2 isoform 22,7
2173558482093729Oxysterol-binding protein-related protein 3 isoform D1,7
29643928259568541P2X purinoceptor 72,2
23775729764370596Pannexin-2 isoform 22
11962678730134291Phosphatidylinositol glycan, class K6,3
7473095931535934PIH1 domain-containing protein 24,1
7473066318920681Plasma cell-induced resident endoplasmic reticulum protein18,5
2964394961271139580Pleckstrin homology domain-containing family G member 4B1,1
1196025792105233975Plectin 1, intermediate filament binding protein 500 kDa1
15042162576483232Polymeric immunoglobulin receptor2,8
12340247951177POU domain, class 2, transcription factor 22,9
222617921499167582Probable phospholipid-transporting ATPase VA3,7
3217124919021015Prostaglandin-H2 D-isomerase17,4
11957888624726680Protease, serine, 3 (mesotrypsin)5,3
12280135238974Protein AMBP; AltName: Full = Alpha-1 microglycoprotein6,5
16241626675887316Protein dpy-19 homolog 21,7
25774326460669420Protein THEMIS isoform 33,1
2964529311208138572Protein timeless homolog1,3
7473352770180649Pseudouridylate synthase 7 homolog-like protein2
16701653610712037Putative nucleosome assembly protein 1-like 610,3
7476035824726522Putative trypsin-612,2
7471278610911855Putative uncharacterized protein FP58818,4
1196319141896211398RAP1 interacting factor homolog (yeast)0,8
12598785661169368Rho-related BTB domain-containing protein 32,5
119620511394319Ribosomal protein S27a41
1262156903280373742RING finger protein 2130,7
2964529781393152659RNA polymerase II-associated protein 10,9
1195737169310828S100 calcium binding protein A8 (calgranulin A)11,8
11957371911413234S100 calcium binding protein A9 (calgranulin B)28,1
450602730735057Serine/threonine-protein phosphatase 4 catalytic subunit4,9
11357660969321Serum albumin precursor34,3
11956908810712318SH3 domain binding glutamic acid-rich protein like 214
11957612226229185Similar to CG12314 gene product7,3
11962092475382996Similar to RIKEN cDNA 4632412N22 gene2,5
2964529992785318182Small subunit processome component 20 homolog0,9
11958949445250195Solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 234,4
11959605631433833Solute carrier family 9 (sodium/hydrogen exchanger), member 84,1
11959979945051876Sorting nexin 44,2
11962850925929439Steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)9,7
11959913350658721TCDD-inducible poly(ADP-ribose) polymerase2,2
10989521852657476Thymocyte selection-associated high mobility group box protein TOX6,1
291045225334233711285Titin isoform N2-A0,3
11960595264171538TNF receptor-associated factor 72,7
585328808635Trefoil factor 322,5
11957361724228050Tropomyosin 314,5
1438930944949863Tubulin alpha-1C chain7,4
471573151124125019Tyrosine-protein kinase JAK31,3
5597776746653619Vimentin19,7
3248341047452883Vitamin D-binding protein precursor17,5
11956866133136884WNT1 inducible signaling pathway protein 34,5
2053231265374145Zinc finger protein 27411,6
14958864367977891Zinc finger protein 2831,9
14056095759068217Zinc finger protein 285A2,4
3058062762672145Zinc finger protein 4412,2
7475940336441163Zinc finger protein 5894,7
11960308164774123Zinc finger protein 5952,5
11959882248556018Zinc finger protein 6392,5
18767192739446069Zinc finger protein 7633,8
7475870380893088Zinc finger protein 8412