Advances in Andrology

Review Article

Advances in Stem Cell Therapy for Erectile Dysfunction

Published studies of stem cell therapy for cavernous nerve injury erectile dysfunction.


Publication year	First author	CN injury method^#	Stem cell type	Modification/supplementation*	Transplantation route	Reference

2004	Bochinski	Crush	Allogeneic ESC	BDNF transduction	IC or intra-MPG	[94]
2006	Kim	Transection	Allogeneic SkMSC	None	IC	[95]
2009	Fall	5-mm resection	Allogeneic BMMNC	None	IC	[96]
2010	Albersen	Crush	Autologous ADSC	None	IC	[97]
2010	Kendirci	Crush	Allogeneic BMSC	p75LNGFR selection	IC	[98]
2011	Lin	5-mm resection	Autologous ADSC	None	Nerve graft	[99]
2011	Woo	Transection	Allogeneic SkMSC	None	IC	[100]
2012	Fandel	Crush	Autologous ADSC	None	IC	[101]
2012	Kim	Crush	Allogeneic BMSC	BDNF transduction	Intra-MPG	[102]
2012	Kovanecz	5-mm resection	Mouse SkMSC	Oral sildenafil	IC	[103]
2012	Piao	Crush	Human ADSC	BDNF PLGA	CN scaffold	[104]
2012	Qiu	Radiation	Allogeneic ADSC	None	IV	[105]
2012	Qiu	Crush	Autologous SVF	None	IC	[106]
2013	Jeong	Crush	Human ADSC	BDNF PLGA	CN scaffold	[107]
2013	Jeong	Crush	Human ADSC	Oral udenafil	CN scaffold	[107]
2013	Kim	Crush	Human ADSC	NGF hydrogel	CN scaffold	[108]
2013	You	Not described	Human BMSC	None	IC + Periprostatic	[109]
2013	You	Stretch	Human ADSC	None	IC + Periprostatic	[110]
2013	Choi	Crush	Human testis SC	None	Periprostatic	[111]
2013	Ying	Crush	Autologous ADSC	None	IC	[112]

For enhancing stem cell’s therapeutic efficacy.
^#All performed in rats.