In Vitro Characterization of Valproic Acid, ATRA, and Cytarabine Used for Disease-Stabilization in Human Acute Myeloid Leukemia:
Antiproliferative Effects of Drugs on Endothelial and Osteoblastic Cells and Altered Release of Angioregulatory Mediators by Endothelial Cells
Figure 4
Altered endothelial cell network formation after treatment with VPA and ATRA. Representative images acquired after 3 days of coculture in the presence of drugs show network formation after (a) treatment with ATRA and (b) treatment with VPA. A representative image of a drug-free control culture is shown for comparison with VPA and ATRA treated cultures. Pa-vSMCs form a confluent layer beneath the HUVECs, but only the fluorescent endothelial cells are visible in the images.
