Review Article
Recent Trends in Detection of Huntingtin and Preclinical Models of Huntington’s Disease
Table 1
In vitro Huntington’s disease models.
| | Cell line | Number of glutamines in the polyQ tract | Full- length/truncated mutant protein | Reporter | Reference |
| | HEK-293 | 82 | N-Terminal part of Htt protein with 171 amino acids | None | [14] |
| HeLa
A 459
Sh-SY5Y | 128 | N-Terminal part of Htt protein with 171 amino acids | Enhanced green fluorescent protein | [15] |
| Cos-7
SH-SY5Y
neuro-2A | 49, 72, 151 | Full length of exon-1 | Enhanced green fluorescent protein | [4] |
| | HEK 293 | 60, 150 | N-Terminal part of exon-1 | Enhanced green fluorescent protein | [16] |
| | PC-12 | 103 | N-Terminal part of exon-1 | Ecdysone inducible system | [17] |
| HEK 293
PC-12 | 150 | N-Terminal part of exon-1 | None | [7] |
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