Research Article

Use of Antiasthmatic Drugs during Pregnancy after the First Trimester and Maternal and Neonatal Outcomes

Table 5

Neonatal diagnosis in infants whose mothers got prescriptions on antiasthmatic drugs during trimester 2 or 3. Odds ratios (OR) or risk ratio (RR) with 95% confidence intervals (95% CI) adjusted for year of delivery, maternal age, parity, smoking, and BMI. Bold text marks statistical significance.

OutcomeWith drugIn populationOR/RR95% CI

Hypoglycemia30968841.251.111.40
Fetal distress61601.060.39–2.31#
Respiratory diagnosis567140551.191.091.29
Apgar score <7 at 5 minutes17040131.211.031.41
Intracranial hemorrhage164830.900.54–1.41
CNS diagnosis12735251.040.87–1.25
Jaundice417120421.010.92–1.12
Any of these diagnoses1212325911.091.061.10

RR as observed/expected number with exact 95% CI.
Information on Apgar score at 5 minutes existed in 10639 infants exposed to antiasthmatic drugs and in 329947 infants in the population.