Research Article
Development and Statistical Optimisation of Buspirone Hydrochloride Buccoadhesive Films
Table 2
full factorial design for the formulation of bucco-adhesive films of Buspirone Hydrochloride.
| | Formulation code | Amount of drug | Total amount of polymer |
Amount of HPMC K15M |
Amount of Eudragit RL-100 |
Amount of permeation enhancer |
Amount of plasticizer | Solvents | | | | | Na-lauryl sulphate | PEG 400 | Water | Alcohol | | In mg | In % | In mg | In % | In mg | In % | In mL | In % | In mL | In mL | In mL |
| | F1 | 50 | 150 | 100 | 150 | 0 | 0 | 5 | 0.009 | 20 | 0.03 | 15 | 0 | | F2 | 50 | 300 | 100 | 300 | 0 | 0 | 5 | 0.018 | 20 | 0.06 | 30 | 0 | | F3 | 50 | 450 | 100 | 450 | 0 | 0 | 5 | 0.027 | 20 | 0.09 | 45 | 0 | | F4 | 50 | 150 | 80 | 120 | 20 | 30 | 5 | 0.009 | 20 | 0.03 | 12 | 7.5 | | F5 | 50 | 300 | 80 | 240 | 20 | 60 | 5 | 0.018 | 20 | 0.06 | 24 | 15 | | F6 | 50 | 450 | 80 | 360 | 20 | 90 | 5 | 0.027 | 20 | 0.09 | 36 | 27.5 | | F7 | 50 | 150 | 66.66 | 100 | 33.33 | 50 | 5 | 0.009 | 20 | 0.03 | 10 | 12.5 | | F8 | 50 | 300 | 66.66 | 200 | 33.33 | 100 | 5 | 0.018 | 20 | 0.06 | 20 | 25 | | F9 | 50 | 450 | 66.66 | 300 | 33.33 | 150 | 5 | 0.027 | 20 | 0.09 | 30 | 37.5 |
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