Research Article
Development and Statistical Optimisation of Buspirone Hydrochloride Buccoadhesive Films
Table 3
Physicochemical parameters of various formulations of buccal films.
| | Formulation code | Surface pH* | Swelling studies | Weight uniformity (mg)* | Thickness (µm)* | Folding endurance* | Drug content* | Bioadhesion strength* (g) |
| | F1 | 6.3 ± 0.02 | 1.22 | 155.2 ± 3.56 | 124.74 ± 1.5 | 29 ± 4 | 98.12 ± 1.26 | 8.87 ± 0.12 | | F2 | 6.6 ± 0.04 | 1.37 | 303.1 ± 4.78 | 211.48 ± 2.2 | 46 ± 3 | 98.17 ± 0.96 | 10.19 ± 0.34 | | F3 | 6.7 ± 0.03 | 1.59 | 456.1 ± 6.13 | 314.22 ± 2.6 | 68 ± 4 | 99.07 ± 0.65 | 13.67 ± 0.49 | | F4 | 6.3 ± 0.04 | 1.09 | 153.2 ± 1.92 | 104.94 ± 0.8 | 21 ± 4 | 98.34 ± 1.37 | 7.38 ± 0.53 | | F5 | 6.6 ± 0.02 | 1.25 | 292.7 ± 3.87 | 202.88 ± 1.6 | 34 ± 4 | 98.67 ± 1.16 | 9.61 ± 0.48 | | F6 | 6.3 ± 0.03 | 1.41 | 441.2 ± 4.27 | 309.82 ± 1.8 | 53 ± 5 | 98.47 ± 1.27 | 11.39 ± 0.65 | | F7 | 6.6 ± 0.04 | 1.01 | 146.1 ± 1.69 | 91.74 ± 0.7 | 19 ± 3 | 98.05 ± 1.22 | 6.93 ± 0.81 | | F8 | 6.7 ± 0.05 | 1.12 | 305.3 ± 2.45 | 193.48 ± 1.3 | 31 ± 5 | 98.21 ± 1.34 | 8.08 ± 0.69 | | F9 | 6.5 ± 0.02 | 1.27 | 447.1 ± 4.43 | 295.22 ± 1.9 | 41 ± 5 | 98.19 ± 1.26 | 9.23 ± 0.78 |
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Data represents mean ± SD, .
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