Research Article
Development and Statistical Optimisation of Buspirone Hydrochloride Buccoadhesive Films
Table 8
Physicochemical properties of optimized formulations during the stability studies.
| | Formulation code | OF1 | OF2 | | Time (Days) | 0 | 30 | 60 | 0 | 30 | 60 |
| | Surface pH | A | 6.1 ± 0.02 | 6.1 ± 0.03 | 6.2 ± 0.04 | 6.3 ± 0.04 | 6.4 ± 0.05 | 6.4 ± 0.07 | | B | 6.1 ± 0.04 | 6.2 ± 0.03 | 6.3 ± 0.05 | 6.3 ± 0.04 | 6.4 ± 0.03 | 6.4 ± 0.07 |
| | Swelling studies | A | 1.18 | 1.18 | 1.17 | 1.13 | 1.12 | 1.12 | | B | 1.18 | 1.17 | 1.17 | 1.13 | 1.11 | 1.08 |
| | Weight uniformity | A | 435.70 ± 1.59 | 426.79 ± 2.28 | 423.54 ± 2.65 | 384.39 ± 2.38 | 378.47 ± 3.32 | 375.76 ± 2.29 | | B | 435.70 ± 1.59 | 423.86 ± 2.18 | 421.65 ± 2.58 | 384.39 ± 2.38 | 372.71 ± 1.63 | 370.34 ± 2.34 |
| | Thickness (µm)* | A | 283.35 ± 1.54 | 282.45 ± 1.65 | 282.13 ± 1.87 | 251.56 ± 1.97 | 249.31 ± 2.12 | 249.06 ± 2.33 | | B | 283.35 ± 1.54 | 280.76 ± 1.32 | 280.45 ± 1.21 | 251.56 ± 1.97 | 247.12 ± 3.34 | 246.41 ± 3.12 |
| | Folding endurance* | A | 134 ± 2 | 131 ± 3 | 129 ± 4 | 126 ± 3 | 122 ± 4 | 121 ± 5 | | B | 134 ± 2 | 130 ± 4 | 128 ± 4 | 126 ± 3 | 121 ± 3 | 119 ± 5 |
| | Drug content* | A | 96.21 ± 2.47 | 95.17 ± 3.12 | 93.28 ± 2.27 | 95.53 ± 1.96 | 93.29 ± 2.78 | 91.18 ± 2.65 | | B | 96.21 ± 2.47 | 93.34 ± 2.19 | 92.19 ± 2.43 | 95.53 ± 1.96 | 92.67 ± 2.79 | 90.29 ± 2.52 |
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A: 30°C ± 2°C/65% ± 5% RH; B: 40°C ± 2°C/75% ± 5% RH.
Data represents mean ± SD, .
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