Research Article
Synthesis of N-Alkyl-2-thiomethyl Benzimidazoles: A Green Approach
Table 1
Preparation of 2a–c from 1 under different green conditions.
| | S. number |
SM | Reagent | Product | Methods | | | | | Green solvents | Microwave irradiation | | Physical grinding | Ethanol | PEG-600 | | | | | Time (Min) | Temp | Yield* (%) | Time (Min) | Temp | Yield* (%) | Time (Min) | Temp (°C) | Yield* (%) | Time (Min) | Temp | Yield* (%) |
| | 1. | 1 | DMS | 2a | 10–15 | RT | 79 | 180 | Reflux | 81 | 180 | 100 | 61 | 2 | RT/450 W | 82 | | DES | 2b | 10–15 | RT | 77 | 180 | Reflux | 79 | 180 | 100 | 58 | 2 | RT/450 W | 81 | | PhCH2Cl | 2c | 10–15 | RT | 75 | 180 | Reflux | 74 | 180 | 100 | 54 | 2 | RT/450 W | 78 |
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Yield refers to recrystallized products.
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