International Scholarly Research Notices

Research Article

Antihyperlipidemic Activity of Aloe succotrina in Rats: Possibly Mediated by Inhibition of HMG-CoA Reductase

Table 3

Effect of dried pulp of Aloe succotrina leaves on serum lipid levels in HFD-induced hyperlipidemic rats.


Group number	Treatment (p.o.)	Dose (kg⁻¹)	Lipid levels (mg/dL)
Group number	Treatment (p.o.)	Dose (kg⁻¹)	TC	TG	HDL-c	VLDL	LDL-c	AI (TG/HDL)

1	Vehicle (1% w/v CMC) (	10 mL
2	Vehicle (1% w/v CMC) + HFD (	10 mL
3	Atorvastatin + HFD (	10 mg
4	Aloe succotrina + HFD (	100 mg
5	Aloe succotrina + HFD (	200 mg

Values are in Mean ± SEM; data was analyzed by one-way ANOVA followed by Tukey-Kramer multiple comparison test. TC—total cholesterol; TG—triglycerides; HDL-c—high density lipoprotein-cholesterol; LDL-c—low density lipoprotein-cholesterol; VLDL—very low density lipoprotein- cholesterol; AI—atherogenic index.
F (4, 20) = 25.856; (for total cholesterol).
F (4, 20) = 10.308; (for triglycerides).
F (4, 20) = 21.007; (for HDL-c).
F (4, 20) = 10.297; (for VLDL).
F (4, 20) = 27.085; (for LDL-c).
F (4, 20) = 4.623; (for AI).
^# and ^### as compared to vehicle treated control; ^a, ^b, and ^c as compared to HFD treated control.