International Scholarly Research Notices

Research Article

Antihyperlipidemic Activity of Aloe succotrina in Rats: Possibly Mediated by Inhibition of HMG-CoA Reductase

Table 4

Effect of dried pulp of Aloe succotrina leaves on liver HMG/mevalonate ratio, malondialdehyde (MDA), and reduced glutathione (GSH) levels of HFD-induced hyperlipidemic rats.
Group numberTreatment (p.o.)Dose (kg−1)Number of animalsHMG/mevalonate ratioMDA levels (nmol/mg tissue)GSH levels ( mol/mg tissue)
1Vehicle (1% w/v CMC)10 mL6
2 Vehicle (1% w/v CMC) + HFD10 mL6
3 Atorvastatin + HFD10 mg3
4Aloe succotrina + HFD100 mg5
5Aloe succotrina + HFD200 mg5
Values are in Mean ± SEM; data was analyzed by one-way ANOVA followed by Tukey-Kramer multiple comparison test.
F (4, 20) = 14.402; (for HMG/mevalonate ratio).
F (4, 20) = 10.117; (for MDA levels).
F (4, 20) = 25.390; (for reduced glutathione levels).
## and ### as compared to vehicle treated control; b and c as compared to HFD treated control.