International Scholarly Research Notices

Research Article

Antihyperlipidemic Activity of Aloe succotrina in Rats: Possibly Mediated by Inhibition of HMG-CoA Reductase

Table 7

Effect of the dried pulp of Aloe succotrina leaves on serum lipid levels in fructose-induced hyperlipidemic rats.


Group number	Treatment (p.o.)	Dose (kg⁻¹)	Lipid Levels (mg/dL)
Group number	Treatment (p.o.)	Dose (kg⁻¹)	TC	TG	HDL-c	VLDL	LDL-c	AI (TG/HDL)

1	Vehicle (1% w/v CMC)	10 mL
2	Vehicle (1% w/v CMC) + fructose (25% w/v)	10 mL
3	Atorvastatin + fructose (25% w/v)	10 mg
4	Aloe succotrina + fructose (25% w/v)	100 mg
5	Aloe succotrina + fructose (25% w/v)	200 mg

in each group; values are in Mean ± SEM; data was analyzed by one-way ANOVA followed by Tukey-Kramer multiple comparison test.
TC—total cholesterol; TG—triglycerides; HDL-c—high density lipoprotein- cholesterol.
LDL-c—low density lipoprotein- cholesterol; VLDL—very low density lipoprotein- cholesterol; AI—atherogenic index.
F (4, 21) = 4.344; (for total cholesterol); F (4, 21) = 8.425; (for triglycerides); F (4, 21) = 6.170; (for HDL-c); F (4, 21) = 8.414; (for VLDL); F (4, 21) = 8.118; (for LDL-c); F (4, 21) =14.361; (for AI).
^#, ^##, and ^### as compared to vehicle treated control; ^a, ^b, and ^c as compared to fructose treated control.