International Scholarly Research Notices

Research Article

Antihyperlipidemic Activity of Aloe succotrina in Rats: Possibly Mediated by Inhibition of HMG-CoA Reductase

Table 8

Effect of dried pulp of Aloe succotrina leaves on liver HMG/mevalonate ratio, MDA, and reduced glutathione (GSH) levels of fructose-induced hyperlipidemic rats.
Group
number		Treatment
(p.o.)		Dose
(kg−1)		HMG/mevalonate ratioMDA levels (nmol/mg tissue)GSH levels ( mol/mg tissue)
1Vehicle (1% w/v CMC)10 mL
2Vehicle (1% w/v CMC) + fructose (25% w/v)10 mL
3Atorvastatin + fructose (25% w/v)10 mg
4Aloe succotrina + fructose (25% w/v)100 mg
5Aloe succotrina + fructose (25% w/v)200 mg
in each group; values are in Mean ± SEM; data was analyzed by one-way ANOVA followed by Tukey-Kramer multiple comparison test.
F (4, 21) = 4.140; (for HMG/mevalonate ratio).
F (4, 21) = 7.607; (for MDA levels).
F (4, 21) = 11.289; (for reduced glutathione).
### as compared to vehicle treated control.
a , b , and c as compared to fructose treated control.