International Scholarly Research Notices / 2014 / Article / Tab 2 / Review Article
Total Ischemic Time as an Independent Predictor of Response to Stem Cell Therapy in Patients with ST Segment Elevation Myocardial Infarction Table 2 (a) Short term studies: baseline and post-PCI measurements of LV parameters and MACE. (b) Long term studies: baseline and post-PCI measurements of LV parameters and MACE.
(a)
Trial Patient number
Baseline
Post-PCI
Baseline
Post-PCI
MACE (percent) BMSC/Placebo BMSC Placebo BMSC Placebo BMSC Placebo BMSC Placebo Cardiovascular death Rehospitalization (HF/MI) Ventricular arrhythmia
Short term Wollert et al., 2004 BOOST [6 ] 30/30 50 (10) 51.3 (9.3) 56.7 (12.5) 52 (12.4) 43 (14.7)** 40.6 (16.9)** 42.4 (23.9)** 42.6 (23.5)** 0/0 3.3/0 3.33/6.7 Chen et al., 2004 [9 ] 34/35 49 (9.0) 48 (10) 67 (3.0) 54 (5.0) 76 (18)** 58 (13)** Janssens et al., 2006 [2 ] 33/34 48.5 (7.2) 46.9 (8.2) 51.8 (8.8) 49.1 (10.7) 42.2 (10.5)** 44.4 (12.3)** 41 (15.5)** 45 (17.9)** 3.0/2.9 0/0 0/8.8 Schächinger et al., 2006 REPAIR-AMI [8 ] 95/92 48.3 (9.2) 46.9 (10.4) 53.8 (10.2) 49.9 (13) 67 (26) 75 (32) 67 (30) 80 (45) 2.1/2.2 0/5.4 4.2/4.4 Ge et al., 2006 TCT-STAMI [10 ] 10/10 53.8 (9.2) 58.2 (7.5) 58.6 (9.9) 56.3 (3.5) 0/0 0/0 0/0 Lunde et al., 2006 ASTAMI [3 ] 45/44 54.8 (13.6) 53.6 (11.6) 56.2 (14.9) 58.1 (11.4) 77 (40) 80 (39) 72 (44) 71 (34) 2.2/2.3 Meluzín et al., 2008 [16 ] 20/20 40 (2.0)*** 40 (2.0)*** 47 (2.0)*** 40 (2.0)*** 100 (11)*** 96 (8.0)*** 95 (6.0)*** 105 (7.0)*** 0/0 5.00/0 0/0 Penicka et al., 2007 +++++ [17 ] 14/10 39 (6.0) 39 (4.0) 45 (9.0) 47 (7.0) 98 (25) 98 (23) 95 (28) 96 (28) 14.3/0 7.1/0 0/0 Tendera et al., 2009 REGENT [4 ] 80/40 37 (19–44)* 39 (23–44)* 40 (24–57)* 39 (32–58)* 92 (53–162)* 87 (72–125)* 91 (45–174)* 96 (54–116)* 1.3/2.5 1.3/5.0 Plewka et al., 2009 [12 ] 38/18 35 (6.0) 33 (7.0) 44 (10) 38 (7.0) 5.3/11.1 Grajek et al., 2010 [5 ] 31/14 50.3 (9.8) 50.8 (12) 47.8 (10.9) 44.9 (11.3) 66.6 (20.3) 60.6 (20.4) 69.8 (23.4) 76.7 (37.2) Piepoli et al., 2010 [18 ] 19/19 36.6 (2.0)*** 37.5 (2.3)*** 45 (2.1)*** 39.7 (2.9)*** 80.1 (6.1)*** 76.5 (8.0)*** 77.7 (6.1)*** 78.3 (8.0)*** Traverse et al., 2010 [19 ] 30/10 49 (9.5) 48.6 (8.5) 55.2 (9.8) 57 (13.4) 46 (26) 40 (11) 39 38 0/0 0/10 0/10
All values are listed as “mean (SD)” unless otherwise denoted. (b)
Trial Patient number
Baseline
Post-PCI
Baseline
Post-PCI
MACE (percent) BMSC/Placebo BMSC Placebo BMSC Placebo BMSC Placebo BMSC Placebo Cardiovascular death Rehospitalization (HF/MI) Ventricular arrhythmia
Long term Meyer et al., 2006 BOOST [20 ] 30/30 50 (10) 51.3 (9.3) 55.9 (14.7) 54.4 (13) 43 (14.7)** 40.6 (16.9)** 42.5 (25)** 41 (24.7)** 0/3.3 3.3/10 0/0 Meluzín et al., 2008 [16 ] 20/20 40 (2.0)*** 40 (2.0)*** 47 (2.0)*** 40 (2.0)*** 100 (11)*** 96 (8.0)*** 97 (5.0)*** 113 (7.0)*** Beitnes et al., 2009 ASTAMI [21 ] 50/50 54.8 (13.6) 53.5 (11.6) 54.9 (13.2) 55.2 (10.6) 77 (40) 80 (39) 79 (51) 77 (44) 2.0/2.0 4.0/2.0 4.0/2.0 Yousef et al., 2009 BALANCE [22 ] 62/62 51.6 (11) 50.8 (10) 56.9 (9.0) 46.9 (8.3) 78.2 (25) 73.4 (20) 63.6 (18) 88.4 (24) 1.6/11.3 Grajek et al., 2010 [5 ] 31/14 50.3 (9.8) 50.8 (12) 47 (7.9) 44.4 (11.7) 66.6 (20.3) 60.6 (20.4) 76.7 (20.3) 79.7 (32.5) 3.2/0 3.2/7.1 Assmus et al., 2010 REPAIR-AMI CMR-Subs [23 ] 26/33 45.4 (9.4) 48.7 (10.4) 50.1 (46.5–53.7)* 43.6 (40.4–46.8)* 68.4 (27.1) 74.2 (31) 91 104 11.5/18.2 3.9/36.4 19.2/18.2 Piepoli et al., 2010 [18 ] 19/19 36.6 (2.0)*** 37.5 (2.3)*** 46.1 (2.6)*** 41 (2.9)*** 80.1 (6.1)*** 76.5 (8.0)*** 67.6 (10.1)*** 76 (4.4)*** 10.5/21.1 26.3/26.3 0/0
All values are listed as “mean (SD)” unless otherwise denoted.
Median (range).
LVESV index.
Standard error.
