Metabolomic Analysis of Liver Tissue from the VX2 Rabbit Model of Secondary Liver Tumors
Table 4
Relevant metabolites and their relative variation between liver tissue samples from adjacent (LT+) and distant (LT−) to tumor implantation site.
Metabolites
Adjacent to tumor (LT+)
Distant to tumor (LT−)
Type related mechanism
Glucose
↑
—
Increase glucose uptake
Lactate
↑
—
Increased -oxidation—increased glycolysis
Glycerol
↑
—
Lipid metabolism
Glycerol-3-phosphate
↑
—
Increased lipids catabolism
Threonic acid
↑
—
Vitamin C metabolite
Inositol
↑
—
Oxidative stress—glutathione synthesis
Ethanolamine
↓
—
Cell replication—membranes
L-serine/L-alanine/glycine
↓
—
Protein synthesis
-alanine
↓
—
Cell replication—uracil catabolism
Aminomalonic acid
↓
—
Oxidative stress—cysteine metabolism
Citrate
↓
—
Citrate cycle—oxidative-redox mitochondrial status
D-Ribose-5-phosphate
↓
—
Purine synthesis
Uracil
↓
—
Cell replication
1-methyl nicotinamide
↑
—
Nicotinamide catabolism—NNMT activation
GABA
↓
—
Cell replication
↑: for relative increase; ↓: for relative decrease; —: for no relative change. LT+: healthy liver tissue adjacent to the tumor and LT−:healthy liver tissue distant from the tumor.