Extraction of Artemisinin, an Active Antimalarial Phytopharmaceutical from Dried Leaves of Artemisia annua L., Using Microwaves and a Validated HPTLC-Visible Method for Its Quantitative Determination
Table 3
Screening of solvents for better extraction of artemisinin through application of microwaves.
Extraction solvent
Soxhlet extractiona
Microwave-assisted extraction (MAE)b
% mean content of artemisinin (dry weight basis)
±SDc
%RSDd
% mean content of artemisinin (dry weight basis)
±SDc
%RSDd
-Hexane
0.772
±0.010
1.30
0.637
±0.012
1.88
Benzene
0.633
±0.009
1.42
0.734
±0.007
0.95
Toluene
0.398
±0.002
0.50
0.747
±0.005
0.67
Chloroform
0.614
±0.013
2.12
0.742
±0.016
2.16
Methylene dichloride
0.580
±0.007
1.21
0.671
±0.001
0.15
Ethyl acetate
0.425
±0.007
1.65
0.693
±0.011
1.59
Acetone
0.622
±0.002
0.32
0.694
±0.007
1.01
Methanol
0.693
±0.007
1.01
0.672
±0.012
1.79
Acetonitrile
0.488
±0.016
3.28
0.698
±0.019
2.72
Soxhlet extractions were performed over a water bath.
bMAE conditions: 100 mg, 14 mesh, 160 watts, 120 seconds, 10 mL × 2 cycles of extraction, and cleanup with 2 mL.
cStandard deviation.
dRelative standard deviation.
