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Infection hosts | Bacteria | Phage | Main outcome | Reference |
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Mice | E. coli | Anti-K1 | Better mice survival rates with phage | Smith and Huggins, 1982 [119] |
BALB/c mice | Klebsiella | Klebsiella pneumoniae bacteriophage | Rescue of generalized Klebsiella infection | Bogovazova et al., 1991 [120] |
Guinea pigs | P. aeruginosa | BS24 | Skin graft protection from bacteria by phage | Soothill, 1994 [75] |
Mice | E. coli, S. typhimurium | λ and P22 | Identification, isolation, and subsequent use of long circulating phage | Merril et al., 1996 [65] |
Chickens and calves | E. coli H247 (O18 : K1 : H7) | ΦR | Protection against morbidity and mortality | Barrow et al., 1998 [121] |
Hamsters | C. difficile | CD140 | 5/6 hamster survived in the phage-treated group compared with none in the control |
Rdamesh, 1999 [122] |
BALB/c mice | Helicobacter pylori | M13 | Reduction of stomach colonization by Helicobacter | Cao et al., 2000 [123] |
Mice | E. faecium | ENB6 | 100% survival 45 min after phage administration | Biswas et al., 2002 [50] |
Mice | V. vulnificus | CK-2, 153A-5, and 153A-7 | Different results of mice protection depending on the phage used. CK-2 and 153A-5 protected mice, whereas 153A-7 did not | Cerveny et al., 2002 [124] |
Mice | E. coli | LW and LH | Mortality rates in mice varied depending on the phage used | Bull et al., 2002 [125] |
Mice | S. aureus | MR11 | Better mouse survival rates with phage administration (MOI40.1) straight after bacterial administration | Matsuzaki et al., 2003 [126] |
Chicken skin | Salmonella enterica and Campylobacter jejuni | P125589 and P22 | Reduction by 2 log units in bacterial abundance over 48 hours | Goode et al., 2003 [127] |
BALB/c mice | Pseudomonas aeruginosa | Phage Pf3R | Higher survival rate and reduced inflammatory response after 12–24 hours | Hagens et al., 2004 [128] |
Rabbits | S. aureus | LS2a | Reduction in abscess size in phage-treated animals and no difference when phage administration was delayed | Wills et al., 2005 [81] |
Mice | E. coli O157 : H7 | SP15, SP21, and SP22 | Successive daily phage administration was required to reduce cell numbers from the gastrointestinal tract | Tanji et al., 2005 [129] |
Chicken | Salmonella enteritidis | CNPSA 1, CNPSA 3, and CNPSA 4 | Reduction of Salmonella enteritidis counts in treated chicken cuts | Fiorentin et al., 2005 [130] |
Chicken | Salmonella typhimurium | Salmonella-specific phages | Reduction in Salmonella counts in cecum and ileum treated chickens | Toro et al., 2005 [131] |
Mice | P. aeruginosa | A392 | 100% survival rate 60 min after phage administration. Reduced survival rates when phages were administrated at 180 and 360 min | Wang et al., 2006b [57] |
Mice | E. coli | 9882 | 100% survival at 24–168 h after phage administration (40 min after bacterial administration) | Wang et al., 2006a [56] |
Shrimp | Vibrio harveyi | Siphoviridae | Improved larval survival | Vinod et al., 2006 [132] |
Mice | P. aeruginosa | Pa1, Pa2, and Pa11 | 87% protection against bacterial infection in mouse burn model compared with 6% in the untreated group after intraperitoneal injection | McVay et al., 2007 [133] |
Mice | P. aeruginosa | KPP10 | Survival rates of 66.7% for the phage-treated group versus 0% for the saline-treated control group | Watanabe et al., 2007 [134] |
Mice | E. coli | T4 and KEP10 | 100% survival rate with T4. 90% survival rate with KEP10 | Nishikawa et al., 2008 [78] |
Mice | E. faecalis | EF24C | 100% survival rate with a phage MOI of 0.1 | Uchiyama et al., 2008 [51] |
Mice | P. aeruginosa | CSV-31 | 100% protection observed when phage was administrated 45 min after bacterial challenge | Vinodkumar et al., 2008 [58] |
Mice | K. pneumonia | SS | Immediate administration of phage resulted in 100% protection; this decreased after 3 h and no protection at 6 h was observed after bacterial challenge | Chhibber et al., 2008 [80] |
Mice | K. pneumoniae | Kpn5 | Phage was able to rescue mice from infection caused by K. pneumoniae |
Kumari et al., 2010 [135] |
Mice | P. aeruginosa | PA1 | No viable bacteria were found in organ samples after 48 h of the phage treatment |
Tiwari et al., 2011 [136] |
Mice | P. aeruginosa | NH-4 and MR299-2 | Killing the pathogen in the lungs of infected mice after phage mixture administration | Alemayehu et al., 2012 [137] |
Mice | E. coli | EC200(PP) | 100% survival mice 1 and 7 h after phage administration |
Pouillot et al., 2012 [138] |
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