Review Article

Bacteriophages and Their Derivatives as Biotherapeutic Agents in Disease Prevention and Treatment

Table 4

Phage lysins targeting pathogenic bacteria.

BacteriaPhageLysinsActivityReferences

S. pneumoniae Cp1Cpl-1MuramidaseLoeffler et al., 2001 [105]; Jado et al., 2003 [107]; McCullers et al., 2007 [108]
S. pneumoniae Dp-1PalAmidaseJado et al., 2003 [107]
S. pyogenes C1C1AmidaseNelson et al., 2001 [106]
B. anthracis γPlyGAmidaseSchuch et al., 2002 [109]
B. anthracis Ames prophagePlyPHAmidaseYoong et al., 2006 [110]
E. faecalis and
E. faecium
Phi1PlyV12AmidaseYoong et al., 2004 [114]
S. aureus MR11MV-LEndopeptidase and amidaseRashel et al., 2007 [99]
S. pyogenes C1PlyCAmidaseHoopes et al., 2009 [152]
S. agalactiae B30GBS lysinMuramidase and endopeptidasePritchard et al., 2004 [153]
S. aureus P68Lys16Endopeptidase Takáč et al., 2005 [154]
S. aureus KLysKAmidase and endopeptidaseO'Flaherty et al., 2005 [53]
S. aureus MR11MV-LAmidase and endopeptidaseRashel et al., 2007 [99]
L. monocytogenes A118Ply118Amidase Gaeng et al., 2000 [155]
L. monocytogenes A511Ply511Amidase Gaeng et al., 2000 [155]
L. monocytogenes A500Ply500EndopeptidaseLoessner et al., 2002 [91]
S. pneumoniae ΦDp-1Pal, SAmidase and endopeptidaseLoeffler et al., 2001 [105]
S. agalactiae LambdaSa1
prophage
LambdaSa1 prophage lysinGlycosidase Pritchard et al., 2007 [156]
S. agalactiae LambdaSa2
prophage
LambdaSa2 prophage lysinGlycosidase and endopeptidase Pritchard et al., 2007 [156]
S. uberis (ATCC700407) prophagePly700Amidase Celia et al., 2008 [111]
S. suis SMPLySMPGlycosidase and endopeptidaseWang et al., 2009 [113]
B. anthracis Bcp1 PlyB, Muramidase Porter et al., 2007 [157]
S. aureus Phi11 and Phi12Phi11 lysinAmidase and endopeptidase Sass and Bierbaum, 2007 [158]
S. aureus ΦMR11 MV-LAmidase and endopeptidaseRashel et al., 2007 [99]
S. aureus ΦH5 LysH5Amidase and endopeptidaseObeso et al., 2008 [112]
S. warneri ΦWMY LysWMY Amidase and endopeptidase Yokoi et al., 2005 [159]
Streptococci (GBS)ΦNCTC 11261PlyGBSMuramidase and endopeptidase Cheng et al., 2005 [160]
C. perfringens Φ3626 Ply3626 AmidaseZimmer et al., 2002 [115]
C. difficile ΦCD27 CD27 lysinAmidase Mayer et al., 2008 [161]
E. faecalis Φ1 PlyV12AmidaseYoong et al., 2004 [114]
A. naeslundii ΦAv-1-Av-1 lysinPutative amidase/
muramidase
Delisle et al., 2006 [162]
L. gasseri ΦgaY LysgaYMuramidase Sugahara et al., 2007 [163]
S. aureus ΦSA4LysSA4Amidase and endopeptidase Mishra et al., 2013 [164]
S. haemolyticus ΦSH2SH2Amidase and endopeptidase Schmelcher et al., 2012 [165]
B. thuringiensis ΦBtCS33PlyBt33Amidase Yuan et al., 2012 [166]
L. monocytogenes ΦP40PlyP40Amidase Eugster and Loessner, 2012 [167]
L. monocytogenes ΦFWLLm3LysZ5Amidase Zhang et al., 2012 [168]
B. cereus ΦBPS13LysBPS13Amidase Park et al., 2012 [169]
S. aureus ΦGH15LysGH15Amidase and endopeptidase Gu et al., 2011 [170]
S. aureus ΦvB_SauS-PLA88HydH5Endopeptidase and glycosidase Rodríguez et al., 2011 [171]
E. faecalis ΦF168/08Lys168Endopeptidase Proença et al., 2012 [172]
E. faecalis ΦF170/08Lys170Amidase Proença et al., 2012 [172]
S. aureus ΦP-27/HPP-27/HPNonspecified Gupta and Prasad, 2011 [173]
C. perfringens ΦSM101PsmMuramidase Nariya et al., 2011 [174]
C. sporogenes Φ8074-B1CS74LAmidase Mayer et al., 2012 [175]
S. typhimurium ΦSPN1SLysin SPN1SGlycosidase Lim et al., 2012 [176]
C. michiganensis ΦCMP1CMP1Peptidase Wittmann et al., 2010 [177]
C. michiganensis ΦCN77CN77Peptidase Wittmann et al., 2010 [177]
A. baumannii ΦAB2LysAB2Glycosidase Lai et al., 2011 [178]
B. cereus ΦB4LysB4Endopeptidase Son et al., 2012 [179]
P. aeruginosa ΦKMVKMV45NonspecifiedBriers et al., 2011 [117]
C. tyrobutyricum ΦCTP1Ctp1lGlycosidase Mayer et al., 2010 [180]
P. aeruginosa ΦELEL188Transglycosylase Briers et al., 2007 [181]
P. aeruginosa ΦKZKZ144Transglycosylase Briers et al., 2007 [181]
S. aureus Ply187Nonspecified Mao et al., 2013 [182]
P. fluorescens ΦOBPOBPgp279Glycosidase Walmagh et al., 2012 [116]
L. monocytogenes ΦP35PlyP35Amidase Eugster et al., 2011 [183]
L. fermentum ΦPYB5Lyb5Muramidase Hu et al., 2010 [184]
S. pneumoniae ΦCP-7Cpl-7Muramidase Bustamante et al., 2010 [185]
P. chlororaphis201 Φ2-1201φ2-1gp229Glycosidase Walmagh et al., 2012 [116]
S. enterica ΦPVP-SE1)PVP-SE1gp146Glycosidase Walmagh et al., 2012 [116]
Corynebacterium ΦBFK20BFK20Amidase Gerova et al., 2011 [186]
E. faecalis ΦEFAP-1EFAL-1Amidase Son et al., 2010 [187]
Lactobacilli lamdaSA2LysA, LysA2, and LysgaYNonspecified Roach et al., 2013 [188]
S. aureus SAL-1Nonspecified Jun et al., 2013 [189]