Research Article

Combined Phosphoproteomics and Bioinformatics Strategy in Deciphering Drug Resistant Related Pathways in Triple Negative Breast Cancer

Figure 1

Phosphoproteins and phosphopeptides identified in TNBC. (a) Venn diagram of the total unique phosphoproteins identified in the two groups of cell lines (chemotherapy-resistant and chemotherapy-sensitive). 287 unique phosphoproteins were found only in resistant cell lines (TNBC-R) and 66 phosphoproteins were found only in sensitive cell lines (TNBC-S). (b) Venn diagram of the total unique phosphopeptides identified in the two groups of cell lines. 1171 unique phosphopeptides were found only in resistant cell lines and 502 phosphopeptides were found only in sensitive cell lines. Peptides with the same sequence, but different phosphorylated sites, were counted as one peptide in this diagram. (c) Pie graph illustrates the biological process of phosphoproteins only identified in resistant TNBC cell lines. (d) Pie graph illustrates the biological process of phosphoproteins only identified in sensitive TNBC cell lines. (e) Pie graph illustrates the cellular compartments of phosphoproteins only identified in resistant TNBC cell lines. (f) Pie graph illustrates the cellular compartments of phosphoproteins only identified in sensitive TNBC cell lines.
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