Research Article

Combined Phosphoproteomics and Bioinformatics Strategy in Deciphering Drug Resistant Related Pathways in Triple Negative Breast Cancer

Figure 3

Phosphopeptides with differential abundance in TNBC cell lines. The hierarchical cluster displayed differential phosphopeptides between resistant and sensitive cell lines by Permutmatrix software. Only phosphopeptide changes with values less than 0.05 were loaded for the analysis. Hierarchical clustering validated the IC50 data that helped classify these TNBC cell lines into two dissimilar groups: chemotherapy-sensitive (MDA-MB-468 and HCC1806) and chemotherapy-resistant (MDA-MB-436, MDA-MB-231, HCC1937, and HCC1187).