Overview of the pathways associated with altered phosphoproteins in the drug resistant of TNBC. PML, AP-1, and HSF-1 were shown to be activated in resistant TNBC cells and might promote downstream signaling including vimentin activation; activation of Cdk5 might also contribute to vimentin and LMNB1 activation to increase EMT in the resistant TNBC cells; EGFR and HGF in TNBC might contribute to the promotion of a multiple drug resistance (MDR) phenotype in resistant cells. Our data suggest that these signals work together to mediate the drug resistance of the TNBC cells.