International Scholarly Research Notices

Research Article

High-Amylose Sodium Carboxymethyl Starch Matrices: Development and Characterization of Tramadol Hydrochloride Sustained-Release Tablets for Oral Administration

Table 1

SD HASCA tablets formulation, press used, target CF, and thickness and selected twice-daily and once-daily tablets.
TW (mg)% of drug (w/w)Tablet pressTarget CF
(tons/cm2), HP		Target thickness
(mm), SSP		Selected twice-daily
and once-daily tablets
40012.5HP2.5 ——
25HP2.5 ——
37.5HP2.5 ——
50HP2.5——
60HP2.5 ——
45022.22HP2.5 —Twice-daily (not selected)
50020HP2.5 ——
30HP2.5 ——
40HP2.5 —Twice-daily (not selected)
50HP2.5 ——
60HP2.5 ——
70014.3HP1 ——
14.3HP1.5 ——
14.3HP2 ——
14.3HP2.5—Once-daily (not selected)
80012.5HP2.5 ——
25HP2.5 —Once-daily (not selected)
37.5HP2.5 ——
50HP2.5 ——
60HP2.5 ——
45022.22 (100 mg)SSP—4.63Twice-daily (selected)
50040 (200 mg)SSP—5.15Twice-daily (selected)
70014.3 (100 mg)SSP—6.98Once-daily (selected)
80025 (200 mg)SSP—7.43Once-daily (selected)