Research Article
Comparison of Heavy Labeled (SIL) Peptide versus SILAC Protein Internal Standards for LC-MS/MS Quantification of Hepatic Drug Transporters
Table 1
MRM parameters of peptide selected for targeted analysis of OATP1B1, OATP1B3, OATP2B1, and P-gp. The labeled amino acid in the internal standard is shown in bold and italic.
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| Isotopic purity of synthetic SIL peptides was 100%. SILAC protein labeling was achieved up to 95.8% (OATP1B1), 98.1% (OATP1B3), 97.2% (OATP2B1), and 98.2% (P-gp). | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||