Nanoemulsion Based Hydrogel for Enhanced Transdermal Delivery of Ketoprofen
Table 6
Permeation parameters for various nanoemulgel formulations.
Formulation code
CADP (mg/cm2)
Flux
Lag time (h)
Drug retained (mg)
NG1
1.10 ± 0.04
0.057 ± 0.06
2.45 ± 0.21
1.40 ± 0.07
NG2
1.15 ± 0.06
0.058 ± 0.35
1.02 ± 0.16
1.35 ± 0.43
NG3
1.62 ± 0.02
0.072 ± 0.52
0.66 ± 0.26
0.88 ± 0.24
NG4
1.41 ± 0.07
0.064 ± 0.06
3.05 ± 0.23
1.09 ± 0.29
NG5
1.58 ± 0.12
0.066 ± 0.14
1.93 ± 0.18
0.92 ± 0.11
NG6
1.82 ± 0.23
0.074 ± 0.25
0.56 ± 0.64
0.68 ± 0.66
NG7
1.19 ± 0.30
0.057 ± 0.32
2.39 ± 0.18
1.31 ± 0.33
NG8
1.32 ± 0.28
0.059 ± 0.17
2.28 ± 0.11
1.18 ± 0.26
NG9
1.50 ± 0.06
0.063 ± 0.29
0.73 ± 0.28
1.00 ± 0.18
NS1
1.08 ± 0.09*
0.041 ± 0.32*
3.68 ± 0.38*
1.42 ± 0.46*
NS2
1.11 ± 0.43*
0.044 ± 0.18*
3.43 ± 0.42*
1.39 ± 0.19*
NS3
1.15 ± 0.42*
0.045 ± 0.26*
3.21 ± 0.42*
1.35 ± 0.25*
Values are expressed as mean ± SD (). CADP: cumulative amount of drug permeated. ; Student’s unpaired -test was used to compare NS batch (formulation prepared without cosurfactant) with NG6 (optimized formulation) for CADP, flux, and lag time.