Research Article
Nanoemulsion Based Hydrogel for Enhanced Transdermal Delivery of Ketoprofen
Table 9
Stability study parameters for nanoemulgel formulations.
| | Time (h) | Temp. | Drug contenta (%) | Transparency | pHa | Phase separation |
| | 1 day | 4°C | 100.50 ± 0.02 | + | 6.63 ± 0.02 | − | | 25°C | 100.3 ± 0.04 | + | 6.62 ± 0.13 | − | | 40°C | 100.24 ± 0.05 | + | 6.61 ± 0.22 | − |
| | 1 month | 4°C | 99.85 ± 0.02 | + | 6.64 ± 0.04 | − | | 25°C | 99.74 ± 0.12 | + | 6.62 ± 0.21 | − | | 40°C | 99.64 ± 0.21 | + | 6.63 ± 0.14 | − |
| | 2 months | 4°C | 99.72 ± 0.04 | + | 6.64 ± 0.18 | − | | 25°C | 99.59 ± 0.07 | + | 6.54 ± 0.16 | − | | 40°C | 99.61 ± 0.21 | + | 6.60 ± 0.22 | − |
| | 3 months | 4°C | 99.42 ± 0.14 | + | 6.63 ± 0.16 | − | | 25°C | 99.51 ± 0.15 | + | 6.61 ± 0.11 | − | | 40°C | 99.16 ± 0.21 | + | 6.63 ± 0.13 | − |
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Values are expressed as mean ± SD (); +: presence; −: absence.
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