Review Article
Neuroprotection in Stroke: Past, Present, and Future
Table 1
Neuroprotective treatments with multiple beneficial effects in stroke.
| Treatment | Species | Model | Benefits | Reference |
| ITH33/IQM9.21 | Mouse | Ischemia | Antiexcitotoxic, antioxidant | Lorrio et al. 2013 [131] | TAT-M9 | Mouse | Ischemia | Antioxidant, antiapoptotic | Guo et al. 2013 [132] | Glycyrrhizic acid | Rat | Ischemia | Anti-inflammatory, antiexcitotoxic, and antioxidant | Kim et al. 2012 [133] | Vitis amurensis extract | Rat | Ischemia | Anti-inflammatory, antiexcitotoxic, antioxidant, and antiapoptotic | Kim et al. 2012 [134] | cis-Hinokiresinols | Rat | Ischemia | Anti-inflammatory, antioxidant | Ju et al. 2013 [135] | Berberine | Rat | Ischemia | Anti-inflammatory, antiapoptotic |
Zhang et al. 2012 [136] | S-Nitrosoglutathione | Rat | Ischemia | Antioxidant, BBB integrity | Khan et al. 2012 [137] | Taurine | Rat | Ischemia | Antiexcitotoxic, antioxidant, and antiapoptotic | Gharibani et al. 2013 [138] | MFG-E8 | Rat | Ischemia | Anti-inflammatory, antiapoptotic | Cheyuo et al. 2012 [139] | Nitrone derivatives | Rat | Ischemia | Antiexcitotoxic, antioxidant | Sun et al. 2012 [140] |
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