Advances in Biology

Review Article

Function, Structure, and Evolution of the Major Facilitator Superfamily: The LacY Manifesto

Table 1

Structural information for MFS transporters. Resolution limits and are stated only for the data sets with the highest resolution (PDB code in bold).


Subfamily	TCDB #*	Protein	Function	PDB code	Resolution ()	Organism	Reference

Oligosaccharide: H⁺ symporter (OHS)	2.A.1.5.1	LacY	Lactose: H⁺ symport	1PV6, 1PV7, 2CFP, 2CFQ, 2V8N, 2Y5Y, 4OAA	2.95 Å (0.298)	E. coli	[15–19]
Organophosphate: Pi antiporter (OPA)	2.A.1.4.3	GlpT	Glycerol-3-phosphate: antiporter	1PW4	3.30 Å (0.325)	E. coli	[20]
Drug: H⁺ antiporter (DHA1)	2.A.1.2.9	EmrD	Multidrug transporter	2GFP	3.50 Å (0.350)	E. coli	[21]
Fucose: H⁺ symporter (FHS)	2.A.1.7.1	FucP	L-Fucose: H⁺ symporter	3O7Q, 3O7P	3.14 Å (0.273)	E. coli	[22]
H⁺-dependent oligopeptide transporter (POT)	2.A.17	PepT	Peptide: H⁺ symporter	4IKV, 4IKW, 4IKX, 4IKY, 4IKZ, 4APS, 2XUT, 4LEP	1.90 Å (0.216)	G. kaustophilus St. thermophiles Sh. oneidensis	[23–26]
Sugar porter (SP)	2.A.1.1.3	XylE	D-Xylose: H⁺ symporter	4GBY, 4GBZ, 4GC0, 4JA3, 4JA4	2.60 Å (0.246)	E. coli	[27, 28]
Solute carrier family (SLC22)	2.A.1.9.10	PiPT	: H⁺ symport	4J05	2.90 Å (0.259)	P. indica	[29]
Sugar porter (SP)	2.A.1.1.3	GlcP	D-Glucose: H⁺ symporter	4LDS	3.20 Å (0.341)	S. epidermidis	[30]
Nitrate: nitrite porter (NNP)	2.A.1.8.10	NarU	/ exchanger	4IU8, 4IU9	3.01 Å (0.316)	E. coli	[31]
Nitrate: nitrite porter (NNP)	2.A.1.8.1	NarK	/H⁺ symporter (K1); / antiporter (K2)	4JR9, 4JRE	2.60 Å (0.261)	E. coli	[32]
Glycoside-pentoside-hexuronide: cation symporter (GPH)	2.A.2.1.1	MelB	Melibiose: Na⁺, Li⁺, or H⁺	4M64	3.35 Å (0.359)	S. typhimurium	[33]
NRT1/PTR family	2.A.17.3	NRT1.1	Low affinity transporter	4CL4, 4CL5, 4OH3	3.25 Å (0.307)	A. thaliana	[34, 35]
Solute carrier family (SLC2A1)	2.A.1.1.28	GLUT1	D-Glucose uniport	4PYP	3.17 Å (0.278)	Homo sapiens	[36]

*TCDB # is the transporter classification number obtained from the Transporter Classification Database, http://www.tcdb.org/.