Identification of Unique miRNA Biomarkers in Colorectal Adenoma and Carcinoma Using Microarray: Evaluation of Their Putative Role in Disease Progression

<table>(a) Zinc-finger<i> BED</i> domain-containing 3 (<i>ZBED3</i>) and the solute carrier family 10 (sodium/bile acid cotransporter family) and me<i>MB</i>er 3 (<i>SLC10A3</i>) genes that were regulated by the 10 common miRNAs showed differential expression patterns between adenoma and carcinoma, respectively. (b) Similarly,<i> FOXQ1 </i>gene expression was 10-fold higher in colon carcinoma when compared to the adenoma of the colon. (c) The upregulation of miR-224 and miR-96 in colon adenoma could cause the downregulation of both<i> ZBED3</i> and<i> SLC10A3</i>. (d) Though both miRNAs were upregulated in colon carcinoma, the expression of<i> ZBED3</i> and<i> SLC10A3</i> was not influenced by these miRNAs.</table>

International Scholarly Research Notices

fig2

Figure 2

Figure 2: Identification of Unique miRNA Biomarkers in Colorectal Adenoma and Carcinoma Using Microarray: Evaluation of Their Putative Role in Disease Progression 

Figure 2 | Identification of Unique miRNA Biomarkers in Colorectal Adenoma and Carcinoma Using Microarray: Evaluation of Their Putative Role in Disease Progression 